Credits: 5

Schedule: 10.09.2018 - 18.10.2018

Teaching Period (valid 01.08.2018-31.07.2020): 



Learning Outcomes (valid 01.08.2018-31.07.2020): 

After the course the student will be able to evaluate and design an asymmetric synthesis for a moderately complex target molecule. The student will be able to evaluate the practical applicability of different strategies (stoichiometric vs catalytic; internal, external vs relayed asymmetric induction). The course will emphasize the synthetic applications to natural products and medicinal chemistry.

The student will have deeper understanding on natural products (secondary metabolites), their structures, occurrence, significance, classification, and biosynthesis.

Content (valid 01.08.2018-31.07.2020): 

Asymmetric synthesis: classification, reaction types, mechanisms. Methods for determining enantiopurity; general methods for asymmetric induction. Reactions of carbonyl compounds and olefins.

Natural products classified according to the classes: their occurrence, biosynthesis and synthesis: sugars, amino acids, nucleic acids, polyketides, terpenes, alkaloids.

Assessment Methods and Criteria (valid 01.08.2018-31.07.2020): 

Lectures, seminar presentation

Workload (valid 01.08.2018-31.07.2020): 

Lectures 24 h
Seminars 8 h
Home problem solving 20 h
Independent homework 70 h

Study Material (valid 01.08.2018-31.07.2020): 

Koskinen, Asymmetric Synthesis of Natural Products, Wiley & Sons, 2012.

Substitutes for Courses (valid 01.08.2018-31.07.2020): 

CHEM-E4245 Natural Product Chemistry or CHEM-E4125 Asymmetric Synthesis

Prerequisites (valid 01.08.2018-31.07.2020): 

CHEM-E4195 Selectivity in Organic Synthesis or equivalent

Grading Scale (valid 01.08.2018-31.07.2020): 

Fail, 1 – 5

Registration for Courses (valid 01.08.2018-31.07.2020): 



Registration and further information