Credits: 5

Schedule: 24.02.2020 - 27.05.2020

Teacher in charge (valid 01.08.2018-31.07.2020): 

Alexander Frey

Teaching Period (valid 01.08.2018-31.07.2020): 

IV-V, course is offered even years

Learning Outcomes (valid 01.08.2018-31.07.2020): 

After the course the student:

  • understands the concepts of Systems biology and how they can be applied to address various research questions
  • knows how –omics technologies are applied to generate data
  • can apply computational tools to treat high-throughput data
  • can differentiate between a reductionistic and a holistic view of a cell
  • can quantitatively describe biological phenomena
  • analyze the behavior of small biological networks using modeling and simulation
  • can model basic microbial metabolism

Content (valid 01.08.2018-31.07.2020): 

The course aims at the analysis and understanding of biological phenomena using –omics tools, mathematical models and simulations. In the course students learn to view the cell as a complex system of interacting components (DNA-protein, protein-protein or metabolite-enzyme). As the individual components often are involved in many different reactions, complex networks are evolving which govern the cellular activities. These networks can be deduced from a global analysis of cells using –omics tools (transcriptomics, proteomics and metabolomics) and other experimental approaches. Methods and strategies for acquisition and analysis of high throughput data will be discussed. Computer exercises will be used to combine theory with the practice. Modeling of metabolic fluxes, their control and thermodynamic balances are practiced. Programs helping in the interpretation of high throughput data will be used.

Assessment Methods and Criteria (valid 01.08.2018-31.07.2020): 

Lectures, computer exercises, assignments and independent studying

Workload (valid 01.08.2018-31.07.2020): 

Total 135h

Lectures 24 h

Computer exercises 24 h

Assignments 30 h

Independent studying 53 h

Exam 4 h

Study Material (valid 01.08.2018-31.07.2020): 

Material to be announced

Course Homepage (valid 01.08.2018-31.07.2020):

Prerequisites (valid 01.08.2018-31.07.2020): 

CHEM-E8120 Cell biology

Grading Scale (valid 01.08.2018-31.07.2020): 

Fail, 1 – 5 grading is based on exam (70%) and computer exercises and assignments (30%).

Registration for Courses (valid 01.08.2018-31.07.2020): 



Registration and further information