Credits: 5

Schedule: 10.09.2019 - 24.10.2019

Teacher in charge (valid 01.08.2018-31.07.2020): 

Tero Eerikäinen

Contact information for the course (applies in this implementation):

Teaching Period (valid 01.08.2018-31.07.2020): 


Learning Outcomes (valid 01.08.2018-31.07.2020): 

After completing the course students will be able to:
1. build kinetic simulation models of the cell growth and product formation
2. connect different models together to build a bioprocess model
3. define parameters for kinetic and static bioprocess models
4. create experimental designs for bioprocess screening and optimization tests
5. create response surface models and define optimum variable values thereof
6. create multivariate models from various data sources including e.g. raw materials, cultivation conditions, product properties, expression data
7. utilize certain chemometric modelling approaches for bioprocess estimation and simulation simulations
8. arrange simple experiments to find out certain kinetic and optimization parameters of a bioprocess
9. estimate the model validity in various cases

Content (valid 01.08.2018-31.07.2020): 

Bioprocess behavior in different modes and modeling principles. Computer-aided bioprocess modeling and simulation. Creating bioprocess models in MATLAB and Simulink environment. Linear and non-linear estimation of the kinetic parameters for types and models. Multivariate modeling possibilities and limitations. Response surface modeling, principal component analysis, neural networks. Use of models as a part of Quality control as process analytical technique. Creating a bioprocess simulation model and validating parameter values from experimental data.

Assessment Methods and Criteria (valid 01.08.2018-31.07.2020): 

Lectures, computer exercises, experimental work, assignments and independent studying

Workload (valid 01.08.2018-31.07.2020): 

Total 135 h = 5cr
Lectures and exercises 24 h, 2x2 h per week
Experimental work 15 h
Assignments 12 h
Independent studying 80 h
Exam 4 h

Study Material (valid 01.08.2018-31.07.2020): 

Material to be announced

Course Homepage (valid 01.08.2018-31.07.2020):

Prerequisites (valid 01.08.2018-31.07.2020): 

CHEM-E3130 Biolab II or similar

Laboratory safety course CHEM-A1010 or CHEM-E0140 (or, alternatively, occupational safety section, which has been taught courses CHEM-A1000 or CHEM-E0100 before the academic year 2017-2018) must be completed before starting the laboratory work.

Grading Scale (valid 01.08.2018-31.07.2020): 

Fail, 1 – 5 grading is based on exam (75%) and exercises and assignments (25%).

Registration for Courses (valid 01.08.2018-31.07.2020): 


Further Information (valid 01.08.2018-31.07.2020): 

 Only available for students majoring in Biotechnology, not available as an elective for other majors.

Details on the schedule (applies in this implementation): 

Time table
37Tue10/09/201910:15-11:45Ke 5Lecture1:
Introduction + Design of experiments (TE)
 Thu12/09/201914:15-15:45B018 (ML3)Exercise1: Modde
design of experiments (TE)
38Tue17.9.10:15-11:45Ke 5Lecture2: Bioreactor
configuration and operation (SB)
 Thu19.9.14:15-15:45Ke3Lecture3: Bioprocess
measurement and control (SB)
39Tue24.9.10:15-11:45B018 (ML3)Exercise2: Matlab
kinetics (TE)
 Thu26.9.14:15-15:45B018 (ML3)Exercise3: Matlab
PID-control (TE)
40Tue1.10.10:15-11:45Ke 5Lecture4: Quality
Control (TE)
 Thu3.10.14:15-15:45B018 (ML3)Exercise4: Neural
networks (TE)
41Tue8.10.10:15-11:45Ke 5Lecture5:
Multivariate modelling (TE)
 Thu10.10.14:15-15:45B018 (ML3)Exercise5: Simca
exercises (TE)
42Tue15.10.10:15-11:45Ke 5Lecture6: Bioprocess
kinetic models (TE)
 Thu17.10.14:15-15:45B018 (ML3)Exercise6: Matlab
parameter estimation (TE)
43Thu25.10.9:00-13:00 Exam
     Labwork scedules will
be arranged separately including:
 TE=Tero Eerikäinen   Bioreactor
installation G1&G2 (about 2 hours)
 SB=Sandip Bankar   kLa-measurement
session G1 (about 3 hours)
session G2 (about 3 hours)
     Bioscreen C,
experiment session G1 & G2 (about 1+1+1 hours)
cultivation G1 (2+2+4 hours)
cultivation G2 (2+2+4 hours)


Registration and further information