Credits: 5

Schedule: 07.01.2020 - 21.02.2020

Teacher in charge (valid 01.08.2018-31.07.2020): 

Alexander Frey

Teaching Period (valid 01.08.2018-31.07.2020): 

III

Learning Outcomes (valid 01.08.2018-31.07.2020): 

After the course the students should be able to: 

  • know the advantages and disadvantages of the different types of expression hosts
  • choose the optimal expression host for a given product
  • identify rate-limiting steps and know how to overcome them
  • modify the expression system for improved production and/or improved characteristics of the target molecule
  • select appropriate tools and strategies for genetic engineering

Content (valid 01.08.2018-31.07.2020): 

This course focuses on the exploitation of cellular systems for the production of enzymes, therapeutic proteins, biochemicals and secondary metabolites. It is located at the interface between biochemistry, microbiology, cell biology and metabolic engineering.

The course aims at the analysis, understanding and recombining of natures’ molecular building blocks using genetic engineering and molecular breeding technologies. This allows the creation of new expression and production systems, ranging from microbial, plant, insect to animal cells.
A project work accompanies the lectures where students design a cell factory.

Assessment Methods and Criteria (valid 01.08.2018-31.07.2020): 

lectures, project work, reporting and self-study

Workload (valid 01.08.2018-31.07.2020): 

Total 135 h

Lectures and Seminars 24h

Project work 40h

Self-study 67h

Exam 4h

Study Material (valid 01.08.2018-31.07.2020): 

Materials distributed during the course

Course Homepage (valid 01.08.2018-31.07.2020): 

https://mycourses.aalto.fi/course/search.php?search=CHEM-E8115

Prerequisites (valid 01.08.2018-31.07.2020): 

CHEM-E8120

Grading Scale (valid 01.08.2018-31.07.2020): 

Fail, 1 – 5; grading is based on examination (70%) and project work (30%)

Registration for Courses (valid 01.08.2018-31.07.2020): 

WebOodi

Description

Registration and further information