The course is providing a comprehensive overview of the developments in pharmaceutical research from historically relevant examples to modern medicinal chemistry and 'biologicals'. The lecture will include in-depth discussions of important aspects such as modes of drug-target interactions, transport and metabolism, structure-activity relationship, and lead optimization and rational design. The course is complemented with general considerations regarding the development of pharmaceuticals and drug-to-market processes.
All slides can be found prior to the lecture day in the materials section.
29.10. General Terms & Basic Principles
30.10. Transport & Metabolism
05.11. Cyclooxygenase Inhibition
06.11. Lipid Regulation
12.11. Steroid Hormones
13.11. Peptidase, Protease & Kinase Inhibition I
20.11. Peptidase, Protease & Kinase Inhibition II
26.11. Microtubule Inhibition
27.11. RNA/DNA Mimicry & Interference
03.12. Neuroactive Drugs
04.12. From Drug Discovery to Approval