General
The knowledge of the principle activation mechanisms in biosynthesis helps us to exploit enzymatic catalysts in organic synthesis. This course will provide a brief introduction into the activation modes of enzymes and discuss opportunities and limitations for synthetic chemistry. Furthermore, the course aims to directly connect features of natural catalysts with the rational development of small molecule analogues as found in modern organocatalysis.
All slides used in the lectures can be found on this page: lecture slides
We will meet on January 12 for the first time to learn more about the individual preknowledge and expectations on the course. A preliminary outline of the content for the first courses is consisting of:
12.1.2016: Introduction (basic principles of catalysis, protein structure and cofactors)
19.1.2016: Oxidoreductases I (carbonyl and imine reductases)
26.1.2016: Oxidoreductases II (oxygenating enzymes)
2.2.2016: Transferases (transaminases)
9.2.2016: Lyases I (decarboxylases and transketolases)
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23.2.2016: Lyases II (aldolases)
1.3.2016: Hydrolases I
8.3.2016: Directed evolution
15.3.2016: Muta- and semisynthesis
22.3.2016: - no lecture -