Please note! Course description is confirmed for two academic years, which means that in general, e.g. Learning outcomes, assessment methods and key content stays unchanged. However, via course syllabus, it is possible to specify or change the course execution in each realization of the course, such as how the contact sessions are organized, assessment methods weighted or materials used.
LEARNING OUTCOMES
After the course the student will be able to
1. interpret MS, IR and NMR spectra
2. solve structures of organic molecules based on MS, IR and NMR spectra
3. describe the functional principles of the MS, IR and NMR spectrometers
Credits: 5
Schedule: 08.09.2020 - 21.10.2020
Teacher in charge (valid 01.08.2020-31.07.2022): Jari Koivisto
Teacher in charge (applies in this implementation): Jari Koivisto
Contact information for the course (valid 13.08.2020-21.12.2112):
Jari Koivisto, room C326c after lectures/exercises
CEFR level (applies in this implementation):
Language of instruction and studies (valid 01.08.2020-31.07.2022):
Teaching language: English
Languages of study attainment: English
CONTENT, ASSESSMENT AND WORKLOAD
Content
Valid 01.08.2020-31.07.2022:
The objective is to learn how to use mass spectrometry (MS), infrared spectroscopy (IR) and nuclear magnetic resonance spectroscopy (NMR) in the structural determination and identification of organic compounds.
After the course, the student should know:
- How to determine molecular weight and molecular formula from the mass spectral data
- How to calculate the Double Bond Equivalent (DBE) based on the molecular formula
- How to identify molecular functional groups from the infrared spectra
- How 1H NMR signal integrals are related to a molecular structure
- How 1H and 13C NMR chemical shifts are related to a molecular structure
- How 1H,1H NMR coupling constants are related to a molecular structure
- How equivalence, symmetry and chirality effect on the NMR spectra
- How to interpret simple 2D NMR spectra
Applies in this implementation:
After the course, the student should know:
- How to determine molecular weight and molecular formula from the mass spectral data
- How to calculate the Double Bond Equivalent (DBE) based on the molecular formula
- How to identify molecular functional groups from the infrared spectra
- How 1H NMR signal integrals are related to a molecular structure
- How 1H and 13C NMR chemical shifts are related to a molecular structure
- How 1H,1H NMR coupling constants are related to a molecular structure
- How equivalence, symmetry and chirality effect on the NMR spectra
- How to interpret simple 2D NMR spectra
Nice to know:
- How MS, IR and NMR spectrometers work
- How fragmentation in the electron ionization (EI) mass spectra is related to a molecular structure
- How nuclear Overhauser effect (NOE) in NMR is related to a molecular structure
- How to determine molecular weight and molecular formula from the mass spectral data
Assessment Methods and Criteria
Valid 01.08.2020-31.07.2022:
Lectures and exercises. The course includes instrument demonstrations. Final exam.
Evaluation is based on the final exam. Please note that this is a problem solving course, i.e. the answers to the exam questions
cannot be found in the textbooks or in the course handout. Therefore, it is important to practise structure determination by solving the exercises.Applies in this implementation:
Evaluation is based on the final exam. Please note that this is a problem solving course, i.e. the answers to the exam questions
cannot
be found in the textbooks or in the course handout. Therefore, it is
important to practise structure determination by solving the exercises.The exam consists of three structure determination problems. One A4 cheat sheet allowed in the exam. 1H and 13C NMR chemical shift tables will be provided.
Workload
Valid 01.08.2020-31.07.2022:
Lectures 28 h
Exercises 18 h
Instrument demonstrations 6 h
Home problem solving 13 h
Independent homework 66 h
Exam 4 hAttendance in the course is not compulsory.
Applies in this implementation:
- Lectures: 6 x 4 h (the last lecture will be spent solving additional exercises)
- Exercises:
6 x 3 h (usually, the first three exercises will require less than 3 h/each) - Instrument
demonstrations: NMR 2 h (probably also MS and IR (max. total 6 h)) - Independent study: 79 h (includes solving exercises at home and preparation to the exam)
- Exam: 4 h
DETAILS
Study Material
Valid 01.08.2020-31.07.2022:
Lecture slides.
Applies in this implementation:
Handout