Please note! Course description is confirmed for two academic years, which means that in general, e.g. Learning outcomes, assessment methods and key content stays unchanged. However, via course syllabus, it is possible to specify or change the course execution in each realization of the course, such as how the contact sessions are organized, assessment methods weighted or materials used.
LEARNING OUTCOMES
After the course the student be able to
- name different biopolymers as pharma targets and describe their general mode of action
- explain how molecules are entering the body, how they are distributed and metabolized
- summarize different aspects related to pharmacokinetics and toxicity
- correlate basic events in the human physiology with specific disease patterns
- recognize characteristic molecular features in the drug design of various blockbuster medications
- analyze structural properties of bioactive molecules and relate them to attractive binding within biological targets
- describe the different stages of drug development from the initial discovery to the market
Credits: 5
Schedule: 27.10.2020 - 03.12.2020
Teacher in charge (valid 01.08.2020-31.07.2022): Jan Deska
Teacher in charge (applies in this implementation): Jan Deska
Contact information for the course (applies in this implementation):
CEFR level (applies in this implementation):
Language of instruction and studies (valid 01.08.2020-31.07.2022):
Teaching language: English
Languages of study attainment: English
CONTENT, ASSESSMENT AND WORKLOAD
Content
Valid 01.08.2020-31.07.2022:
The development of effective medications against infective diseases and physiological disorders has had a major transformative impact on our societies, and pharmaceutical industries are nowadays an important factor in many countries' economies.
The course on Medicinal Chemistry provides a comprehensive overview of the developments in pharmaceutical research, from historically relevant examples to modern medicinal chemistry and 'biologicals'. Particular emphasis is put on the understanding of molecular principles and biosynthetic relationships.
The contact sessions will include in-depth discussions of important aspects such as modes of drug-target interactions, transport & metabolism, structure-activity relationship, and lead optimization & rational design. The course is complemented with general considerations regarding the development of pharmaceuticals and drug-to-market processes.
Assessment Methods and Criteria
Valid 01.08.2020-31.07.2022:
The student success is assessed based on:
- an online questionnaire,
- three online quizzes, and
- a final written exam
Workload
Valid 01.08.2020-31.07.2022:
Contact sessions 24 h
Reflection and online tasks 48 h
Independent self-studies 60 h
Written examination 3h
DETAILS
Study Material
Valid 01.08.2020-31.07.2022:
A comprehensive handout and in-class exercise materials are provided, with no additional literature needed. The course is based on: G. Klebe, Drug design – Methodology, concepts and mode-of-action, Springer, 2013.
Substitutes for Courses
Valid 01.08.2020-31.07.2022:
replaces CHEM-E8130 Medicinal Chemistry
Prerequisites
Valid 01.08.2020-31.07.2022:
- Orgaanisen kemian perusteet, or similar, and
- Biotieteen perusteet
SDG: Sustainable Development Goals
3 Good Health and Well-being
- Opettaja: Deska Jan