CHEM-E4220 - Medicinal Chemistry D, Lecture, 2.11.2021-14.12.2021

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Please note! Course description is confirmed for two academic years, which means that in general, e.g. Learning outcomes, assessment methods and key content stays unchanged. However, via course syllabus, it is possible to specify or change the course execution in each realization of the course, such as how the contact sessions are organized, assessment methods weighted or materials used.

LEARNING OUTCOMES

After the course the student be able to

  • name different biopolymers as pharma targets and describe their general mode of action
  • explain how molecules are entering the body, how they are distributed and metabolized
  • summarize different aspects related to pharmacokinetics and toxicity
  • correlate basic events in the human physiology with specific disease patterns
  • recognize characteristic molecular features in the drug design of various blockbuster medications
  • analyze structural properties of bioactive molecules and relate them to attractive binding within biological targets 
  • describe the different stages of drug development from the initial discovery to the market

Credits: 5

Schedule: 02.11.2021 - 14.12.2021

Teacher in charge (valid for whole curriculum period):

Teacher in charge (applies in this implementation): Jan Deska, Jenny Thors

Contact information for the course (applies in this implementation):

CEFR level (valid for whole curriculum period):

Language of instruction and studies (applies in this implementation):

Teaching language: English. Languages of study attainment: English

CONTENT, ASSESSMENT AND WORKLOAD

Content

  • valid for whole curriculum period:

    The development of effective medications against infective diseases and physiological disorders has had a major transformative impact on our societies, and pharmaceutical industries are nowadays an important factor in many countries' economies.

    The course on Medicinal Chemistry provides a comprehensive overview of the developments in pharmaceutical research, from historically relevant examples to modern medicinal chemistry and 'biologicals'. Particular emphasis is put on the understanding of molecular principles and biosynthetic relationships.

    The contact sessions will include in-depth discussions of important aspects such as modes of drug-target interactions, transport & metabolism, structure-activity relationship, and lead optimization & rational design. The course is complemented with general considerations regarding the development of pharmaceuticals and drug-to-market processes.

Assessment Methods and Criteria

  • valid for whole curriculum period:

    The student success is assessed based on:

    • an online questionnaire,
    • three online quizzes, and
    • a final written exam

Workload

  • valid for whole curriculum period:

    Contact sessions 24 h

    Reflection and online tasks 48 h

    Independent self-studies 60 h

    Written examination 3h

DETAILS

Study Material

  • valid for whole curriculum period:

    A comprehensive handout and in-class exercise materials are provided, with no additional literature needed. The course is based on: G. Klebe, Drug design Methodology, concepts and mode-of-action, Springer, 2013.

Substitutes for Courses
Prerequisites
SDG: Sustainable Development Goals

    3 Good Health and Well-being

FURTHER INFORMATION

Further Information

  • valid for whole curriculum period:

    Teaching Period:

    2020-2021 Autumn II

    2021-2022 Autumn II

    Course Homepage: https://mycourses.aalto.fi/course/search.php?search=CHEM-E4220

    Registration for Courses: In the academic year 2021-2022, registration for courses will take place on Sisu (sisu.aalto.fi) instead of WebOodi.

Rules of Conduct - Students´ Rights and Responsibilities (in force from 1 August 2020)

Aalto University Code of Academic Integrity and Handling Violations Thereof