CHEM-E4109 - Modern Methods in Biocatalysis D, Lecture, 1.3.2022-13.4.2022

Topic outline

• Seminar presentations
  Welcome to the seminar section. The seminar is taking place on two days, April 12 an April 13. You pick one of them, you prepare your own talk and you engage in the discussions. That's it, no need to show up on the other day. Unless you like of course. Maybe there's a interesting topic presented on the other day and you are certainly welcome to also join the second day.

  I've been collecting what I consider interesting articles in the wider field of biocatalysis from the past few years. According to your feedback from learning diary #1, I divided the papers into the different areas of research trying to provide a sufficiently large selection so that everyone can find something or their liking. Remember the author name and year, you'll need that info for the choice tool below.

  Please also keep in mind, that I am happy to accept your own suggestions if you have a particular topic in mind that is not listed here. Just send me an email. 

  
  

  Possible Topics

  Protein engineering
  

  Narayan 2022: Biocatalytic oxidative cross-coupling reactions for biaryl bond formation, https://doi.org/10.1038/s41586-021-04365-7

  Arnold 2016: Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life, https://doi.org/10.1126/science.aah6219

  Wu 2021: Development of a versatile and efficient C–N lyase platform for asymmetric hydroamination via computational enzyme redesign, https://doi.org/10.1038/s41929-021-00604-2

  Grogan 2013: Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products, https://doi.org/10.1021/ja4051235

  Loiseleur 2022, Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens, https://doi.org/10.1038/s41467-022-27999-1

  Leys 2021: Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production, https://doi.org/10.1038/s41467-021-25598-0

  
  

  Biocatalytic cascades

  Micklefield 2021: Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis, https://doi.org/10.1038/s41929-021-00603-3
  

  Yang 2019: Design of an in vitro biocatalytic cascade for the manufacture of islatravir, https://doi.org/10.1126/science.aay8484

  Busto 2015: Vinylation of Unprotected Phenols Using a Biocatalytic System, https://doi.org/10.1002/anie.201505696

  Turner 2017: Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing, https://doi.org/10.1002/anie.201705848

  
  

  Synthetic methodology & mechanisms

  Zhao 2020: Photoenzymatic enantioselective intermolecular radical hydroalkylation, https://doi.org/10.1038/s41586-020-2406-6

  Buller 2022: Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction, https://doi.org/10.1038/s41929-022-00743-0
  

  Kroutil 2017: Biocatalytic Friedel–Crafts Acylation and Fries Reaction, https://doi.org/10.1002/anie.201703270

  Fasan 2016: Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle–Kirmse Reaction, https://doi.org/10.1002/anie.201607278

  
  

  Metabolic engineering

  Keasling 2019, Complete biosynthesis of cannabinoids and their unnatural analogues in yeast, https://doi.org/10.1038/s41586-019-0978-9

  Erb 2021, A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation, https://doi.org/10.1038/s41929-020-00557-y
  

  Kim 2021: Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli, https://doi.org/10.1038/s41589-020-00684-4

  Li 2020: One-pot biocatalytic route from cycloalkanes to α,ω‐dicarboxylic acids by designed Escherichia coli consortia, https://doi.org/10.1038/s41467-020-18833-7

  
  

  • Select activity Pick your seminar slot

    

    Pick your seminar slot Choice

    If you are limited to one day, please make your choice of topic and date asap. Everyone else, wait until tomorrow (Thursday March 17) before locking your preferred topic. There's plenty to choose from and all articles are amazing 😉 
    

    Again, if you have something else in mind, you can also talk about work that is not listed below. Pick one of the "I have an own topic"-entries and send me an email with your suggestion.

  • Select activity Pre-seminar discussion

    

    Pre-seminar discussion Scheduler