Credits: 5

Schedule: 25.02.2019 - 11.04.2019

Teaching Period (valid 01.08.2018-31.07.2020): 


Learning Outcomes (valid 01.08.2018-31.07.2020): 

After the course the student will have deeper understanding on
- polarity & orbital control
- stereoelectronics
- regioselectivity & diastereoselectivity

Content (valid 01.08.2018-31.07.2020): 

The course takes up previously reviewed organic transformations and discusses them in the context of regio- and diastereoselectivity. The course will provide the tools to perform the conformational analyses and employ general concepts such as polarity control and orbital control to predict reaction outcomes and relative configurations in C-C and C-heteroatom bond forming transformations. Reactions will include the addition of simple carbon nucleophiles, enolates and P-, S-, and Si-stabilized carbanions to carbonyls and olefinic double bonds as well as cycloadditions and rearrangements.

Assessment Methods and Criteria (valid 01.08.2018-31.07.2020): 

Lectures, exercises, seminar presentations

Workload (valid 01.08.2018-31.07.2020): 

Lectures 24 h
Exercise discussions 8 h
Seminar 8 h
Independent homework 90 h

Study Material (valid 01.08.2018-31.07.2020): 

Clayden, Greeves, Warren, Wothers, Organic Chemistry; chapters 27, 32-35
Brückner, Harmata, Organic Mechanisms; selected material

Prerequisites (valid 01.08.2018-31.07.2020): 

CHEM-E4150 Reactivity in Organic Synthesis or equivalent

Grading Scale (valid 01.08.2018-31.07.2020): 

Fail, 1 – 5

Registration for Courses (valid 01.08.2018-31.07.2020): 



Registration and further information