LEARNING OUTCOMES
After the course the students should be able to:
- know the advantages and disadvantages of the different types of expression hosts
- choose the optimal expression host for a given product
- identify rate-limiting steps and know how to overcome them
- modify the expression system for improved production and/or improved characteristics of the target molecule
- select appropriate tools and strategies for genetic engineering
Credits: 5
Schedule: 10.01.2023 - 24.02.2023
Teacher in charge (valid for whole curriculum period):
Teacher in charge (applies in this implementation): Alexander Frey
Contact information for the course (applies in this implementation):
CEFR level (valid for whole curriculum period):
Language of instruction and studies (applies in this implementation):
Teaching language: English. Languages of study attainment: English
CONTENT, ASSESSMENT AND WORKLOAD
Content
valid for whole curriculum period:
This course focuses on the exploitation of cellular systems for the production of enzymes, therapeutic proteins, biochemicals and secondary metabolites. It is located at the interface between biochemistry, microbiology, cell biology and metabolic engineering.
The course aims at the analysis, understanding and recombining of natures molecular building blocks using genetic engineering and molecular breeding technologies. This allows the creation of new expression and production systems, ranging from microbial, plant, insect to animal cells.
A project work accompanies the lectures where students design a cell factory.
Assessment Methods and Criteria
valid for whole curriculum period:
Fail, 1 – 5; grading is based on examination (60%) and project work (40%)
Workload
valid for whole curriculum period:
Total 135 h
Lectures and Seminars 20 to 24 hours
Project work 50 hours
Self-study 57 to 61 hours
Exam 4 hours
DETAILS
Substitutes for Courses
valid for whole curriculum period:
Prerequisites
valid for whole curriculum period:
SDG: Sustainable Development Goals
3 Good Health and Well-being
13 Climate Action
FURTHER INFORMATION
Further Information
valid for whole curriculum period:
Teaching Language : English
Teaching Period : 2022-2023 Spring III
2023-2024 Spring IIIA course implementation may be cancelled if the number of students enrolled to the course implementation does not meet the required minimum of five students. In the case of cancelled course implementations, the students enrolled to them must be provided with an alternative way of completing the course or be advised to take some other applicable course.