CHEM-C2330 - Biochemistry, Lecture, 6.9.2022-17.10.2022

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Please note! Course description is confirmed for two academic years, which means that in general, e.g. Learning outcomes, assessment methods and key content stays unchanged. However, via course syllabus, it is possible to specify or change the course execution in each realization of the course, such as how the contact sessions are organized, assessment methods weighted or materials used.

LEARNING OUTCOMES

After completing the courese, the students should be able to: 

- explain how enzyme catalysis works (on a very fundamental level: drawing "reaction coordinate vs. free energy" diagrams) 

- name different methods for protein engineering and evaluate their potential 

- draw chemical reaction mechanisms relevant for biochemistry ("pushing electrons") 

- describe the composition and reactivity of important biomolecules 

- visualize the 3D structure of proteins via the softwar PyMol 

- present scientific concepts to peers 

- search and evaluate state-of-the-art science 

Credits: 5

Schedule: 06.09.2022 - 17.10.2022

Teacher in charge (valid for whole curriculum period):

Teacher in charge (applies in this implementation): Silvan Scheller

Contact information for the course (applies in this implementation):

CEFR level (valid for whole curriculum period):

Language of instruction and studies (applies in this implementation):

Teaching language: English. Languages of study attainment: English

CONTENT, ASSESSMENT AND WORKLOAD

Content

  • valid for whole curriculum period:

    Repetition of fundamental chemistry related to biochemistry. Revision of amino acids and non-covalent forces responsible for the 3D structure of proteins (going more into detail than CHEM-A1310 or CHEM-C1300). Bioenergetics (thermodynamics relevant for biochemistry). Theoretic analysis of enzyme catalysis. Draw reaction coordinates and interpret them. Principles of how to develop an enzyme inhibitor. Enzyme kinetics with one substrate. Comparison of enzyme catalysis vs. classical catalysis. Cofactors. Enzyme engineering and selected strategies to do this, including directed evolution. Biocatalysis and applications. 

     

     

     

Assessment Methods and Criteria

  • valid for whole curriculum period:

    Exercises

    Group work

    Exam

Workload

  • valid for whole curriculum period:

    Total 135h = 5cr
    Lectures 24 h

    Exercises 10h
    Assignments or exercises 36 h

    Group work 30 h
    Other independent studying 32 h
    Exam 3 h

DETAILS

Substitutes for Courses
Prerequisites
SDG: Sustainable Development Goals

    3 Good Health and Well-being

    4 Quality Education

    7 Affordable and Clean Energy

    12 Responsible Production and Consumption

FURTHER INFORMATION

Further Information

  • valid for whole curriculum period:

    Teaching Language : English

    Teaching Period : 2022-2023 Autumn I
    2023-2024 Autumn I

    Enrollment :

    The enrollment deadline ends 7 days before the first lecture. 

    A course implementation may be cancelled if the number of students enrolled to the course implementation does not meet the required minimum of five students. In the case of cancelled course implementations, the students enrolled to them must be provided with an alternative way of completing the course or be advised to take some other applicable course.

Rules of Conduct - Students´ Rights and Responsibilities (in force from 1 August 2020)

Aalto University Code of Academic Integrity and Handling Violations Thereof